![]() This achievement indicated that routine affordable and accurate whole-genome sequencing (WGS) is achievable and beneficial. In 2010, Complete Genomics hit another milestone for being the first to provide $5,000 genome using DNBSEQ™, the most efficient and accurate MPS, before later becoming part of MGI. With advantages including increased accuracy, decreased duplicates and reduced index misassignments, it is the exact technology currently used in all MGI's state-of-the-art sequencing instruments. Today, we call this core technology DNBSEQ™.ĭNBSEQ TM sequencing arrays have no clonal errors or index hopping and generate higher signal density than regular DNA arrays for greatly improved detection accuracy. In 2005, with my team I invented patterned arrays of DNA nanoballs (DNB) that expanded MPS' capabilities to more efficient and larger-scale sequencing. I was motivated to bring this to life through Complete Genomics. MPS was critical in enabling routine, affordable sequencing of individual genomes. It was also the impetus for me to start my own company, Complete Genomics, to maximize the potential of MPS. It proved that biology is entering larger scale projects, much like sending human beings to the moon. It allowed exome and panel sequencing using capture probe and primers based on the genome sequence. It made shorter reads more usable because we now had a reference. It prompted this important demand for the sequencing of more genomes. At the time, we did not understand most of them, but nonetheless, there was a list. In essence, HGP was about making a list of genome parts. Around this time, my idea of massively parallel sequencing (MPS) using DNA microarrays prepared by emulsion PCR on microbeads was also born. As part of HGP, I proposed and eventually moved to the US to develop DNA sequencing-by-hybridization, which at the time enabled more-efficient higher throughput sequencing. My involvement with HGP began in 1987, precisely when the initiative was kickstarted, in the form of a $150,000 grant opportunity provided by the US Department of Energy, to improve technologies for genome analysis, including sequencing. Having spent north of three decades of my career contributing to our collective understanding of the human genome, I look back at my achievements and those of my peers with great pride. ![]() Initially a targeted effort to understand the impact of radiation on human beings, the Human Genome Project (HGP) set in motion countless advancements that have revolutionized healthcare and brought us the sub-$100 genome available today. This year marks the 20 th anniversary of the completion of the first human genome sequence, which was mapped out on April 14, 2003. Radoje Drmanac, CSO of MGI, Co-Founder of Complete Genomics
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